89464-63-1DMOG

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商品编号：D136754

库存现货：9

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商品名称：89464-63-1DMOG
商品毛重：0.00
单位：件
上架时间：2017-11-02 08:27:55

名称: DMOG英文名称: DMOG≥98% (HPLC)产品编号 D136754
CAS号: 89464-63-1分子式 C₆H₉NO₅分子量175.14
MDL号 MFCD05865098

标识符号	GHS07
信号词	Warning
危害声明	H302
WGK德国	3

属性

存贮条件	储存温度-20°C

描述

产品介绍	Dimethyloxallyl Glycine(DMOG)是可渗透入细胞的HIF-1α脯氨酰羟化酶（HIF-PH）竞争性抑制剂。
别名	二甲基乙二酰氨基乙酸;二甲基草酰甘氨酸;N-(Methoxyoxoacetyl)-glycine methyl ester; Dimethyloxallyl Glycine
生化机理	DMOG is a cell permeable prolyl-4-hydroxylase inhibitor, which upregulates HIF (hypoxia-inducible factor). The protein level of HIF-1α subunit is post-transcriptionally regulated by prolyl and asparaginyl hydroxylase (PAH). Suppression of PAH activity increases endogenous HIF-1α levels. DMOG is a cell permeable, competitive inhibitor of prolyl hydroxylase domain-containing proteins (PHDs and HIF-PHs). It has been discovered that the DMOG posseses neuroprotective effect on NFG deprived cell cultures through preservation of glucose metabolism. DMOG also attenuates myocardial injury in a rabbit ischemia reperfusion model. DMOG is more potent than the older inhibitor 4-Phenyl-pyridine-2,5-dicarboxylic acid (R395889; Sigma-Aldrich rare chemicals library). The IC50 is 5.18 μM.