120-08-1滨蒿内酯

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商品编号：D101245

库存现货：9

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商品名称：120-08-1滨蒿内酯
商品毛重：0.00
单位：件
上架时间：2017-11-02 08:13:26

名称: 滨蒿内酯英文名称: 6,7-Dimethoxycoumarin分析标准品,≥98%产品编号 D101245
CAS号: 120-08-1分子式 C₁₁H₁₀O₄分子量206.19
Beilstein号 EC号 204-369-0MDL号 MFCD00006871PubChem编号 24855271

标识符号	GHS06
信号词	Danger
风险声明 (欧洲)	22,36
安全声明（欧洲）	26
警示性声明	P301+P310,P305+P351+P338
危害码（欧洲）	Xn
危害声明	H301,H319
个人防护设备	dust mask type N95 (US),Eyeshields,Faceshields,Gloves
RTECS	GN6550000
WGK德国	3
UN代码	2811

属性

密度	1.2480
熔点	143-145°C
溶解性	Soluble in DMSO (15 mg/ml), and water (partly miscible).

描述

产品介绍	Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. It has been shown to clear the accumulation of bilirubin by the activation of CAR in neonatal jaundice. Other studies show that scaparone inhibits lipopolysaccharide (LPS)-induced tissue factor (TF) expression in HUVECs and that it acts as an anti-inflammatory compound. TCPOBOP also transactivates CAR, however, scoparone can activate murine and human CAR. Scaparone can increase dopamine release by synapsin I phosphorylation through activation of PKA and CaMKII? in PC12 cells. It can also activate neurite outgrowth and improve dopamine biosynthesis in PC12 cells.
别名	蒿属香豆素;Scoparone;6,7-Dimethylesculetin;6,7-Dimethoxy-2H-chromen-2-one;6,7-Dimethoxy-2-benzopyrone
应用	An agent that can up-regulate the expression and activate CAR