188817-13-2SC-560

￥0.00 ￥~~0.00~~

商品编号：C135780

库存现货：9

顾客评分：

(已有0人评价)

购买数量：

+ -

添加收藏

热卖商品

商品名称：188817-13-2SC-560
商品毛重：0.00
单位：件
上架时间：2017-11-01 20:10:37

名称: SC-560英文名称: SC-560≥98%(HPLC)产品编号 C135780
CAS号: 188817-13-2分子式 C₁₇H₁₂ON₂ClF₃分子量352.74
MDL号 MFCD02179214PubChem编号 24278696

标识符号	GHS07
信号词	Warning
警示性声明	P261-P305 + P351 + P338
危害声明	H315-H319-H335
个人防护设备	dust mask type N95 (US), Eyeshields, Gloves
WGK德国	3

属性

密度	1.3300
熔点	1.56
沸点	440.58° C at 760 mmHg
存贮条件	储存温度2-8°C

描述

产品介绍	Selective cyclooxygenase-1 (COX-1) inhibitor, exhibiting 700-fold selectivity for COX-1 over COX-2.
别名	5-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑;5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethyl pyrazole; 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
生化机理	SC 560 is reported to be a Cox-1 and Cox-2 inhibitor, and is highly selective for Cox-1 (IC50 of 0.009 μM) over Cox-2 (IC50 of 6.3 μM). SC 560 also inhibits UTP-stimulated and basal cAMP levels. Cox-1 is shown to catalyze the conversion of Arachidonic Acid (20:4, n-6) (sc-200770) into PGH2 (Prostaglandin H2, sc-201266), which is the precursor of thromboxanes and other prostaglandins, therefore SC 560 also suppresses TXB2 (Thromboxane B2, sc-201452) and PGE2 (Prostaglandin E2, sc-201225) production. SC 560 also displays the ability to induce cell growth inhibition by causing cell cycle arrest at the G1 phase. Mechanistic studies show that SC 560 causes apoptosis of cells by eliciting reactive oxygen species and simultaneously decreasing the levels of anti-apoptotic proteins XIAP and survivin. Additional experiments suggest that SC 560 also activates caspase-3 and caspase-7 which results in apoptosis of cells.
应用	A highly potent and selective inhibitor of Cox-1