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名称: 栗精胺英文名称: Castanospermine98%产品编号 C130954
CAS号: 79831-76-8分子式 C8H15NO4分子量189.21
Beilstein号 3588654EC号 MDL号 MFCD00017555PubChem编号 24892642
标识符号 | GHS07 |
信号词 | Warning |
警示性声明 | P280 |
危害声明 | H302-H312-H332 |
个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
WGK德国 | 3 |
溶解性 | Soluble in 1N HCl (20 mg/ml, yielding a clear, colorless to faint yellow solution), and DMSO (75 mM). Insoluble in water. |
存贮条件 | 储存温度 2-8°C |
别名 | (1S,6S,7R,8R,8aR)-1,6,7,8-四羟基八氢吲哚里西定;(1S,6S,7R,8R,8aR)-八氢-1,6,7,8-吲嗪四醇; 1,6,7,8-四羟基八氢吲嗪;(1S,6S,7R,8R,8aR)-1,2,3,5,6,7,8,8a-八氢吲嗪-1,6,7,8-四醇;栗树精胺;(1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizidine; (1S,6S,7R,8R,8aR)-Octahydro-1,6,7,8-indolizinetetrol; 1,6,7,8-Tetrahydroxyoctahydroindolizine; 6,7-Diepicastanospermine |
生化机理 | Castanospermine, originally derived from Castanosperum australe has been shown to be a potent inhibitor of almond emulsion β-glucosidase, and also to inhibit fungal β-xylosidase. Other studies show castanospermine to have the capacity to make viral glycopeptides more susceptible to enzyme treatment. Additionally, castanospermine may have the potential ability to inhibit syncytium formation between HIV-infected and CD4-expressing cells and may also interfere with infectivity. It has also been demonstrated that this agent inhibits inflammation at the level of leukocyte extravasation in rat models of experimental adjuvant-induced arthritis and autoimmune encephalomyelitis. Castanospermine is an inhibitor of Glucosidase I, Maltase-glucoamylase, and MANBA. |
应用 | A glycosidase inhibitor and antiinflammatory agent. |
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