17321-77-6Clomipramine HCl

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商品编号：C129687

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商品名称：17321-77-6Clomipramine HCl
商品毛重：0.00
单位：件
上架时间：2017-11-01 18:30:34

名称: Clomipramine HCl英文名称: Clomipramine HCl≥99%产品编号 C129687
CAS号: 17321-77-6分子式 C₁₉H₂₃ClN₂·HCl分子量351.31
Beilstein号 EC号 241-344-3MDL号 MFCD00069234PubChem编号 24278087

标识符号	GHS07
信号词	Warning
警示性声明	P261-P280-P305 + P351 + P338
危害声明	H302 + H312 + H332-H315-H319-H335
个人防护设备	dust mask type N95 (US), Eyeshields, Gloves
RTECS	HN9055000
WGK德国	3

属性

敏感性	对热和光敏感
溶解性	Soluble in water (125 mg/ml), ethanol (70 mg/ml at 25 °C), chloroform (1:3), DMSO (70 mg/ml at 25 °C), and dilute aqueous acid.

描述

产品介绍	Clomipramine HCl 是Clomipramine的盐酸盐，抑制5-羟色胺转运蛋白（SERT），去甲肾上腺素转运体（NET）和多巴胺转运蛋白（DAT），Ki分别为0.14， 54和3 nM。
别名	盐酸氯米帕明;氯丙咪嗪盐酸盐;Anafranil hydrochloride;Clomipramine hydrochloride
生化机理	Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is an ST (serotonin transporter/SERT), SLC6A2 (norepinephrine transporter/NET), and DAT (dopamine transporter) blocker with Ki of 0.14, 54 and 3 nM, respectively. Clomipramine hydrochloride is a tricyclic antidepressant, a norepinephrine-reuptake inhibitor, and an antiobsessional drug. Clomipramine hydrochloride is an inhibitor of D2 receptor (Ki = 162 nM), D3 receptor (Ki = 30 nM), AR (α1-adrenergic receptor, Ki = 3.2 nM), α2-adrenergic receptor (Ki = 525 nM), H1 receptor (Ki = 31 nM), mACh receptors (Ki = 37 nM), 5-HT2A receptor (Ki = 36 nM), 5-HT2C receptor (Ki = 65 nM), 5-HT3 receptor (Ki = 85 nM), 5-HT6 receptor (Ki = 54 nM), 5-HT7 receptor (Ki = 127 nM), D1 receptor (Ki = 219 nM).
备注	Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.
应用	A selective ST, SLC6A2, and DAT inhibitor