9001-12-1胶原蛋白酶来源于溶组织梭菌(类型1)

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商品编号：C128702

库存现货：9

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商品名称：9001-12-1胶原蛋白酶来源于溶组织梭菌(类型1)
商品毛重：0.00
单位：件
上架时间：2017-11-01 18:30:19

名称: 胶原蛋白酶来源于溶组织梭菌(类型1)英文名称: Collagenase from Clostridium histolyticum(Type 1)≥125 units/mg dry weight产品编号 C128702
CAS号: 9001-12-1EC号 232-582-9MDL号 MFCD00130830

标识符号	GHS07, GHS08
信号词	Danger
风险声明 (欧洲)	R36/37/38;R42
安全声明（欧洲）	S22;S24;S26;S36/37
警示性声明	P261,P305+P351+P338,P342+P311
危害码（欧洲）	Xn
危害声明	H315,H319,H334,H335
个人防护设备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
WGK德国	1

属性

存贮条件	储存温度 2-8°C

描述

产品介绍	Crude collagenase preparations contain several isoforms of two different collagenases, a sulfhydryl protease, clostripain, a trypsin-like enzyme, and an aminopeptidase. This combination of collagenolytic and proteolytic activities is effective at breaking down intercellular matrices, the essential part of tissue dissociation. One component of the complex is a hydrolytic enzyme which degrades the helical regions in native collagen preferentially at the Y-Gly bond in the sequence Pro-Y-Gly-Pro, where Y is most frequently a neutral amino acid. This cleavage yields products susceptible to further peptidase digestion. Crude collagenase is inhibited by metal chelating agents such as cysteine, EDTA or o-phenanthroline but not DFP. It is also inhibited by α2-macroglobulin, a large plasma glycoprotein. Ca2+ is required for enzyme activity. Particular enzymatic profiles of each collagenase have been correlated with the tissues from which the cells for study were obtained (or with the uses to which the cells are put) and as a result of the correlations several types of crude collagenases have been established by Aladdin: Types 1, 2, 3, and 4.
别名	梭菌肽酶 A;Clostridiopeptidase A
备注	The original balance of enzymatic activities. Each lot assayed for collagenase, caseinase, clostripain and tryptic activities. Suggested for epithelial, liver, lung and adrenal primary cell isolations. A dialyzed, lyophilized powder.
应用	This collagenase has been tested with cell lines to verify the product is not cytotoxic. Collagenase is typically used to digest the connective components in tissue samples to liberate individual cells. The concentration for cartilage dispersal is 1-2 mg/ml, but literature searches should be performed for species specific and/or tissue specific concentrations.