842133-18-0Canagliflozin

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商品编号：C126191

库存现货：9

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商品名称：842133-18-0Canagliflozin
商品毛重：0.00
单位：件
上架时间：2017-11-01 18:29:55

名称: Canagliflozin英文名称: Canagliflozin≥98%产品编号 C126191
CAS号: 842133-18-0分子式 C₂₄H₂₅FO₅S分子量444.52
Beilstein号 EC号 MDL号 PubChem编号

属性

溶解性	DMSO 89 mg/mL Water Ethanol
存贮条件	储存温度-20°C

描述

产品介绍	Canagliflozin inhibits Na+- dependent 14C-AMG uptake in a concentration-dependent fashion. It is a novel C-glucoside with thiophene ring.
别名	坎格列净;(1S)-1,5-脱氢-1-C-[3-[[5-(4-氟苯基)-2-噻吩基]甲基]-4-甲基苯基]-D-葡萄糖醇;JNJ 24831754ZAE; JNJ 28431754; JNJ 28431754AAA; TA 7284;(2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
生化机理	Canagliflozin(JNJ 24831754ZAE; JNJ 28431754; JNJ 28431754AAA; TA 7284) is an experimental drug being developed by Johnson & Johnson for the treatment of type 2 diabetes.Canagliflozin(JNJ 24831754ZAE; JNJ 28431754; JNJ 28431754AAA; TA 7284) is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine.
备注	Canagliflozin is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM, exhibits 413-fold selectivity over hSGLT1.