92307-52-3牛促肾上腺皮质激素释放激素

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商品编号：C118797

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商品名称：92307-52-3牛促肾上腺皮质激素释放激素
商品毛重：0.00
单位：件
上架时间：2017-11-01 18:27:27

名称: 牛促肾上腺皮质激素释放激素英文名称: Corticotropin Releasing Factor bovine≥90% (HPLC)产品编号 C118797
CAS号: 92307-52-3分子式 C₂₀₆H₃₄₀N₆₀O₆₃S分子量4697.33
MDL号 MFCD00081537

个人防护设备	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国	3

属性

存贮条件	储存温度:-20°C

描述

产品介绍	氨基酸序列 Ser-Gln-Glu-Pro-Pro-Ile-S?er-Leu-Asp-Leu-Thr-Phe-Hi?s-Leu-Leu-Arg-Glu-Val-Leu?-Glu-Met-Thr-Lys-Ala-Asp-?Gln-Leu-Ala-Gln-Gln-Ala-H?is-Asn-Asn-Arg-Lys-Leu-Le?u-Asp-Ile-Ala Corticotropin Releasing Factor,bovine, (C206H340N60O63S1), a peptide with the sequence H2N-SQEPPISLDLTFHLLREVLEMTKADQLAQQAHNNRKLLDIA-amide, MW= 4697.4. Corticotropin-releasing hormone (CRH) also known as corticotropin-releasing factor (CRF) is a peptide hormone and neurotransmitter involved in the stress response. It belongs to corticotropin-releasing factor family(1). Its main function is the stimulation of the pituitary synthesis of ACTH.Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 196-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Increased CRH production has been observed to be associated with Alzheimer's disease and major depression(2), and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to being produced in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta, CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition.
别名	CRF, CRH;CRF, CRH
生化机理	CRF是一种是由垂体前叶释放促肾上腺皮质激素和内啡肽的下丘脑肽。在中枢神经系统中它也是一种神经递质，涉及自主神经和内分泌对刺激的反应。