118909-22-1马来酸维吖啶

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商品编号：A132455

库存现货：9

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商品名称：118909-22-1马来酸维吖啶
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:41:26

名称: 马来酸维吖啶英文名称: Hydroxytacrine maleate salt98%产品编号 A132455
CAS号: 118909-22-1分子式 C₁₇H₁₈N₂O₅

分子量330.34

MDL号 MFCD00069287

组合的产品项目
货号	规格	库存	价格	数量
A132455-1g	98%	上海(预计3-7周) 北方(预计3-7周)
A132455-250mg	98%	上海(预计3-7周) 北方(预计3-7周)

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属性

溶解性	Soluble in water (5 mg/mL warm), DMSO (25 mg/mL), and ethanol (10 mg/mL).
存贮条件	储存温度-20°C，充氩储存

描述

别名	;Velnacrine maleate;9-Amino-1,2,3,4-tetrahydro-1-acridinol (2Z)-2-butenedioate;9-amino-1,2,3,4-tetrahydroacridin-1-ol maleate
生化机理	Hydroxytacrine maleate is a cholinesterase inhibitor and a potential Alzheimer’s therapeutic of low toxicity. Exhibits biochemical and pharmacological profile similar to tacrine (THA) except that it is far less toxic and without measurable liver toxicity in humans. Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor (anticholinesterase). It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease, and was marketed under the trade name Cognex. Major form of metabolism is in the liver via hydroxylation of benzylic carbon by CYP450. This forms the major metabolite 1-hydroxy-tacrine (velnacrine) which is still active. Hydroxytacrine maleate is an inhibitor of AChE.
应用	A cholinesterase inhibitor that exhibits a biochemical profile very similar to tacrine

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分子量330.34
MDL号 MFCD00069287 关于我们

属性

溶解性	Soluble in water (5 mg/mL warm), DMSO (25 mg/mL), and ethanol (10 mg/mL).
存贮条件	储存温度-20°C，充氩储存

描述

别名	;Velnacrine maleate;9-Amino-1,2,3,4-tetrahydro-1-acridinol (2Z)-2-butenedioate;9-amino-1,2,3,4-tetrahydroacridin-1-ol maleate
生化机理	Hydroxytacrine maleate is a cholinesterase inhibitor and a potential Alzheimer’s therapeutic of low toxicity. Exhibits biochemical and pharmacological profile similar to tacrine (THA) except that it is far less toxic and without measurable liver toxicity in humans. Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor (anticholinesterase). It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease, and was marketed under the trade name Cognex. Major form of metabolism is in the liver via hydroxylation of benzylic carbon by CYP450. This forms the major metabolite 1-hydroxy-tacrine (velnacrine) which is still active. Hydroxytacrine maleate is an inhibitor of AChE.
应用	A cholinesterase inhibitor that exhibits a biochemical profile very similar to tacrine