81403-68-1Alfuzosin hydrochloride

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商品编号：A129804

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商品名称：81403-68-1Alfuzosin hydrochloride
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:41:15

名称: Alfuzosin hydrochloride英文名称: Alfuzosin hydrochloride≥98%产品编号 A129804
CAS号: 81403-68-1分子式 C₁₉H₂₇N₅O₄.HCl分子量425.91
Beilstein号 EC号 MDL号 MFCD00879135PubChem编号

标识符号	GHS07
信号词	Warning
危害声明	H302
个人防护设备	dust mask type N95 (US), Eyeshields, Gloves
WGK德国	3

属性

溶解性	Soluble in DMSO (85 mg/ml at 25 °C), methanol, ethanol (85 mg/ml at 25 °C), and PBS (pH 7.2) (~1 mg/ml). Insoluble in water.

描述

产品介绍	Alfuzosin HCl 是一种α1受体拮抗剂，用于治疗良性前列腺增生（BPH）。
别名	阿夫唑嗪盐酸盐; N-[3-[(4-氨基-6,7-二甲氧基-2-喹唑啉基)(甲基)氨基]丙基]四氢-2-呋喃酰胺盐酸盐;4-氨基-6,7-二甲氧基-2-[甲基[3-[(四氢-2-呋喃甲酰)氨基]丙基]氨基]喹唑啉盐酸盐;盐酸阿夫唑嗪;N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide hydrochloride; Uroxatral hydrochloride;4-Amino-6,7-dimethoxy-2-[methyl[3-[(tetrahydro-2-furoyl)amino]propyl]amino]quinazoline Hydrochloride;Alfuzosin HCl
生化机理	Alfuzosin hydrochloride is a uro-selective α 1 adrenoceptor antagonist that does not distinguish between α 1 subtypes. In addition, in vitro studies indicate that Alfuzosin hydrochloride can relax corpus cavernosum tissue. Also Alfuzosin hydrochloride has been seen to inhibit the increase of intraurethral pressure caused by phenylephrine. Studies suggest that isocratic reversed phase high-performance liquid chromatographic (HPLC) with ultraviolet detection at 245 nm can be used, along with a stainless steel analytical column to determine the presence of Alfuzosin hydrochloride in solution. Furthermore, alternate studies indicate that Alfuzosin hydrochloride can be detected in human plasma using a spectrofluorimetric method which relies on measuring the native fluorescence of Alfuzosin hydrochloride in deionized water using λ excitation at 325.0 nm and λ emission at 390.0 nm along with solid phase extraction.
备注	Alfuzosin(Uroxatral) is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).
应用	An α 1 adrenoceptor antagonist.