2627-69-2Acadesine

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商品编号：A129749

库存现货：9

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商品名称：2627-69-2Acadesine
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:41:14

名称: Acadesine英文名称: Acadesine≥98%产品编号 A129749
CAS号: 2627-69-2分子式 C₉H₁₄N₄O₅分子量258.23
Beilstein号 EC号 220-097-5MDL号 MFCD00869751PubChem编号 24724407

标识符号	GHS07
信号词	Warning
警示性声明	P261-P305 + P351 + P338
危害声明	H315-H319-H335
个人防护设备	dust mask type N95 (US), Eyeshields, Gloves
WGK德国	3

属性

溶解性	Soluble in water (9 mg/ml), and DMSO (75 mM).
存贮条件	储存温度-20°C

描述

产品介绍	Acadesine导致ZMP的积累，Acadesine模仿AMP对AMPK和AMPK的刺激作用。
别名	阿卡地新; 5-氨基-1-beta-D-呋喃核糖基-1H-咪唑-4-甲酰胺;AICAR;5-Amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide;5-Aminoimidazole-4-carboxamide ;1-β-D-ribofuranoside ; N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
生化机理	AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
备注	Acadesine results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK. Phase 3.
应用	An inhibitor of the transcription of PPARα, the coactivation of PPARα.