154229-18-2Abiraterone Acetate

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商品编号：A129731

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商品名称：154229-18-2Abiraterone Acetate
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:41:13

名称: Abiraterone Acetate英文名称: Abiraterone Acetate≥99%产品编号 A129731
CAS号: 154229-18-2分子式 C₂₆H₃₃NO₂分子量391.55
Beilstein号 EC号 MDL号 PubChem编号

属性

溶解性	Soluble in methanol (sparingly), water (
存贮条件	储存温度-20°C

描述

产品介绍	Abiraterone Acetate是Abiraterone的醋酸盐形式，是一种甾体类细胞色素CYP17抑制剂，IC50为72 nM。
别名	乙酸阿比特龙酯;CB 7630, CB-7630;(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate
生化机理	Abiraterone acetate has been seen to be a novel steroidal inhibitor of CYP17A1(C17,20 lyase), a cytoochrome P450 complex, a rate-limiting enzyme in androgen biosynthesis resulting in inhibtion of testosterone production in both the adrenals and the testes. It has been observed to decrease the DHEA, androstenedione and testosterone. The compound has been shown to be approximately 21-24 times more potent than ketoconazole and liarozole in CYP17A1 lyase inhibition. In medicine, Abiraterone is used for treating prostate cancer.
备注	Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM.
应用	A steroidal inhibitor of CYP17A1 in androgen biosynthesis