328543-09-5AG14361

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商品编号：A125467

库存现货：9

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商品名称：328543-09-5AG14361
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:40:37

名称: AG14361英文名称: AG14361≥98%产品编号 A125467
CAS号: 328543-09-5分子式 C₁₉H₂₀N₄O分子量320.4

属性

溶解性	DMSO ≥20mg/mL Water
存贮条件	储存温度 -20°C

描述

产品介绍	AG14361是PARP1抑制剂，Ki
别名	AG 14361; 2-(4-((二甲基氨基)甲基)苯基)-5,6-二氢咪唑并(4,5,1-jk)(1,4)苯并二氮杂卓-7(4H)-酮;AG 14361; AG-14361;2-(4-((dimethylamino)methyl)phenyl)-5,6-dihydroimidazo(4,5,1-jk)(1,4)benzodiazepin-7(4h)-one; Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one
生化机理	AG14361 is at least 1000-fold more potent than the benzamides.AG14361 treatment before irradiation statistically significantly increases the sensitivity to radiation therapy of mice bearing LoVo xenografts. AG14361 statistically significantly increases blood flow in xenografts and thus potentially increases drug delivery to tumor xenografts.