38966-21-1艾菲地可宁

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商品编号：A102398

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商品名称：38966-21-1艾菲地可宁
商品毛重：0.00
单位：件
上架时间：2017-10-31 22:35:00

名称: 艾菲地可宁英文名称: Aphidicolin98%产品编号 A102398
CAS号: 38966-21-1分子式 C₂₀H₃₄O₄分子量338.48
Beilstein号 4689958EC号 MDL号 MFCD00083214PubChem编号 24890452

安全声明（欧洲）	22,24
个人防护设备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECS	PB9185000
WGK德国	3

属性

敏感性	对光敏感
密度	1.2200
溶解性	Soluble in ethanol (1 mg/ml,stable at least a week at 4°C.), DMSO (10 mg/ml,stable at least six weeks at -20°C.), and methanol (10 mg/ml). Insoluble in water.
存贮条件	储存温度2-8°C

描述

产品介绍	Aphidicolin is a tetracyclic diterpene antibiotic and DNA synthesis inhibitor isolated from Cephalosporium aphidicola. Aphidicolin is reported to specifically inhibit DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases. This compound blocks the cell cycle at early S phase and has been reported to be useful for synchronizing cell cycles in cultured eukaryotic cells. This compound is also noted to induce apoptosis in HeLa S3 cells after 18-24 hours of the cell cycle.
别名	Aphidicolin;APC
应用	A novel tetracyclic diterpene antibiotic and also a DNA synthesis inhibitor in eukaryotes